Promensil Double Strength
30 capsules (1 month pack)
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Explore This Product
Promensil is based on naturally occurring red clover isoflavones which work like the oestrogen hormone. Low levels of oestrogen is the main cause of symptoms related to menopause.
This product is for maintenance of general health among women in menopause. It is recommended for women during the early stages of menopause as a starter dose but can be used throughout menopause and beyond.
Promensil red clover contains 4 key isoflavones (Genistein, Daidzein, Biochanin A and Formonoetin) that help balance female hormones by mimicking the effects of oestrogen in the body, which in turn help support women during the menopause.
Promensil’s red clover isoflavones are naturally occurring and are not chemically synthesised. The red clover used in Promensil, from which the extract is taken, is cultivated and harvested in respect of GAP (Good Agricultural Practices), ensuring full process traceability.
Promensil is suitable for vegans and vegetarians and does not cause weight gain
Active ingredient: Red clover (Trifolium pratense) extract 200mg; standardised as natural isoflavones: 80mg
Bulking agents (Dicalcium Phosphate, Microcrystalline Cellulose)
Tablet Coating (Hydroxypropylmethyl Cellulose, Colour: Iron Oxides, Glazing Agent: Polyethylene Glycol)
Anti-caking agents (Silicon Dioxide, Magnesium Stearate)
Emulsifier (Cross-linked sodium carbxymethyl cellulose)
Antioxidant (Alpha Tocopherol).
How it works:
Red clover (Trifolium pratense) is a herbal extract, which is high in isoflavones (natural plant oestrogens). Red Clover isoflavones mimic the action of oestrogen which women in menopause start to lose and this loss causes menopause related symptoms.
Isoflavones are widely used by women to maintain their health and vitality especially during the time of menopause. Isoflavones can be taken through normal diet (e.g., soya) but it is difficult to get to the recommended daily intake of 40-80mg.
Some clinical trial data have shown that Promensil has an effect on hot flush among women in menopause. (for example, Study 1 below) However, in some other clinical trials, Promensil did not demonstrate statistically significant effect on hot flush. (e.g., Study 2 below)
NHS England takes a view that prescription medicine should be the standard therapy for hot flush. It states that
‘Data for all non-hormonal treatments are limited, so use should be restricted to more symptomatic women who are unable to or do not wish to take oestrogen. Most studies have been short-term, and the long-term efficacy and safety of non-hormonal treatments for menopausal hot flushes is not known’. (4)
There are some data that Promensil might have protective effect on patient’s cardiovascular function. (e.g., Study 3)
In this randomized, double blind, placebo-controlled trial 30 women with more than 12 months amenorrhoea and experiencing more than five flushes per day were enrolled. All received single blind placebo tablets for 4 weeks and were subsequently randomized to either placebo or 80 mg isoflavones for a further 12 weeks. Efficacy was measured by the decrease in number of hot flushes per day and changes in Greene Climacteric Scale Score.
In this study, treatment with 80 mg isoflavones (Promensil) per day resulted in a significant reduction in hot flushes from baseline. At the end of the study there was a significant decrease in hot flushes of 44% between the active and placebo group, demonstrating the effectiveness of Promensil in the management of hot flushes.
Van de Weijer PHM, et al. Isoflavones from red clover (Promensil) significantly reduce menopausal hot flush symptoms compared with placebo. Maturitas 2002 Jul 25; 42(3):187-93. (1)
Although the study provides some evidence for a biological effect of Promensil, neither supplement had a clinically important effect on hot flashes or other symptoms of menopause.
Design, Setting, and Participants Randomized, double-blind, placebo-controlled trial of menopausal women, aged 45 to 60 years, who were experiencing at least 35 hot flashes per week.
Intervention After a 2-week placebo run-in, 252 participants were randomly assigned to Promensil (82 mg of total isoflavones per day), Rimostil (57 mg of total isoflavones per day), or an identical placebo, and followed-up for 12 weeks.
Main Outcome Measure The primary outcome measure was the change in frequency of hot flashes measured by participant daily diaries. Secondary outcome measures included changes in quality of life and adverse events.
Results Of 252 participants, 246 (98%) completed the 12-week protocol. The reductions in mean daily hot flash count at 12 weeks were similar for the Promensil (5.1), Rimostil (5.4), and placebo (5.0) groups. In comparison with the placebo group, participants in the Promensil group (41%; 95% confidence interval [CI], 29%-51%; P = .03), but not in the Rimostil group (34%; 95% CI, 22%-46%; P = .74) reduced hot flashes more rapidly. Quality-of-life improvements and adverse events were comparable in the 3 groups.
Conclusion Although the study provides some evidence for a biological effect of Promensil, neither supplement had a clinically important effect on hot flashes or other symptoms of menopause.
Jeffrey A et al. Phytoestrogen Supplements for the Treatment of Hot Flashes: The Isoflavone Clover Extract (ICE) StudyA Randomized Controlled Trial
Journal of American Medical Association. 2003;290(2):207-214. (2)
Methods: The study comprised 40 healthy postmenopausal women with an average age of 56 years. The women were divided into two groups: 22 were allocated to a red clover-derived isoflavone medication group, and 18 were allocated to a non-medication group. Total blood cholesterol, cholesterol fractions and triglycerides in the women of both groups were investigated before treatment and at 4-month intervals over the following 12 months.
Results: Both total serum cholesterol and low-density lipoprotein (LDL) cholesterol levels, as well as triglyceride levels, were decreased significantly in the group receiving phytoestrogens. However, high-density lipoprotein (HDL) cholesterol showed a significant increase. (Note from LivBio: LDL cholesterol is called ‘bad colesterol’ as it takes cholesterol to one’s arteries. So decreasing level of LDL is desirable. HDL helps to lose one’s excess cholesterol and Is less likely to end up on one’s arteries.)
Conclusion: Red clover phytoestrogen supplementation in postmenopausal women had favorable metabolic effects on serum lipids. Furthermore, red clover phytoestrogens have no side-effects and can be considered safe.
Terzic MM et al. Influence of red clover-derived isoflavones on serum lipid profile in postmenopausal women. Journal of Obstetrics and Gynaecology Research. 2009 Dec; 35(6):1091-5. (3)
Maintenance of general health during menopause
Reduction of hot flush
Promensil has been in use over 20 years in a number of countries including UK and is generally considered to be safe.
(From the manufacturer’s website)
Take one tablet daily with your main meal and a cold drink, continuously at around the same time each day or as directed by your healthcare professional. Initially we recommend a minimum of 12 weeks intake to feel the full effect.
Do not exceed the recommended dosage. Food supplements should not replace a balanced diet and healthy lifestyle. If you are under medical supervision, please consult your healthcare professional before use. Not for use by pregnant or lactating women. Keep out of sight and reach of children. Store below 25°C in a dry place, out of direct sunlight.
Promensil supplements are suitable to be taken daily for as long as needed to help maintain a comfortable menopause. You should be able to assess the full benefits of taking Promensil after the first 8-12 weeks.
Suitable for women with symptoms who are unable to or do not wish to take oestrogen. Larger, more standardised head-to-head and placebo-controlled trials are needed to establish the efficacy and safety of these treatment options.
Generally considered safe. However, following points should be noted:
- uncertainty about potential serious interactions with other drugs (including tamoxifen, anticoagulants and anticonvulsants).
- insufficient evidence to suggest that they are safe to be taken by women with oestrogen-dependent cancer – eg, breast cancer.
- no safety data available in relation to their risk of venous thromboembolism (VTE).
- Relief for hot flushes and night sweats
- General health and well-being during and after the menopause
- Maintaining bone health
- Maintaining cholesterol at a healthy level
- Not all red clover products are the same. Whereas some red clover extracts contain little or no isoflavones, Promensil uses a standardised patented extraction process to guarantee purity and quantity of the core, active ingredient at the optimal levels (40-80mg).
- Promensil’s red clover isoflavones are naturally occurring and are not chemically synthesised. The red clover used in Promensil, from which the extract is taken, is cultivated and harvested in respect of GAP (Good Agricultural Practices), ensuring full process traceability. The harvest–time coincides with the balsamic period of the plant and has been established over the years through close collaboration and partnerships between the factory that produces the extract and each farm.
- Red clover and soy are both legumes and belong to the same family of plants. The main difference is that red clover contains four active isoflavones whereas soy only has two. The extra two found in red clover are commonly found in other legumes such as chick peas and lentils.
- Red clover isoflavones also have better bioavailability, take less time to reach maximum concentration in the body and keep maximum concentration for longer, compared to soya isoflavones.
- It is recommended that 1 tablet is taken daily with food. Usually 1 tablet per day suits most women either taken in the morning with breakfast or in the evening depending on when you feel it is most appropriate for you.
- Do not exceed the recommended dosage. Food supplements should not replace a balanced diet and healthy lifestyle. If you are under medical supervision, please consult your healthcare professional before use. Not for use by pregnant or lactating women. Keep out of sight and reach of children. Store below 25°C in a dry place, out of direct sunlight.
- Promensil supplements are suitable to be taken daily for as long as needed to help maintain a comfortable menopause.
- You should be able to assess the full benefits of taking Promensil after the first 8-12 weeks.
- Promensil is not recommended for use during pregnancy or lactation. The product is not recommended for use by children. Use only as directed.
- If you are under medical supervision, please consult your healthcare professional before use.
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